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Fatigue and hypertension were the most common clinically relevant adverse events associated with enzalutamide treatment.

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Studies that have analyzed disease-free survival (defined by either biochemical or clinical progression) have also shown no statistically significant difference with NAD.

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Luteinizing hormone-releasing hormone (LHRH) antiagonists work like agonists, but they reduce testosterone levels more quickly and do not cause tumor flare like the agonists do.

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Eligible patients had not received cytotoxic chemotherapy, ketoconazole, or abiraterone acetate, had an Eastern Cooperative Oncology Group performance status grade of 0 or 1 (no symptoms or ambulatory but restricted in strenuous activities), and were either asymptomatic (score of 0 to 1) or mildly symptomatic (score of 2 to 3), as measured on the Brief Pain Inventory Short Form question 3 (on which scores range from 0 to 10, with higher scores indicating a greater severity of pain).

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The treatment effect of enzalutamide on PFS was consistently favorable across all prespecified subgroups (), including disease state (nonmetastatic v metastatic) at study entry.

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